intensely or extremely bad or unpleasant in degree or quality

very strong or vigorous

severely simple

unsparing and uncompromising in discipline or judgment

causing fear or anxiety by threatening great harm

very bad in degree or extent

a respiratory disease of unknown etiology that apparently originated in mainland China in 2003; characterized by fever and coughing or difficulty breathing or hypoxia; can be fatal

a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

detached by cutting

to a severe or serious degree

with sternness; in a severe manner

causing great damage or hardship

used of the degree of something undesirable e.g. pain or weather

something hard to endure

extreme plainness

excessive sternness